Endocrine Abstracts

Introduction: Despite development of diagnostic and therapeutic possibilities pancreatic neuroendocrine tumours remain still a clinical challenge.Case report: A 31-year-old woman after cholecystectomy performed in 2007. MRI performed in November 2008 due to abdominal pain revealed tumour of the pancreas – 35×42×32 mm. In May 2009 patient underwent partial excision of the pancreas. On histopathological examination neuroendocrine tumour NET ...

Introduction: Peptide receptor radionuclide therapy is indicated in case of patients with disseminated neuroendocrine tumors and is usually considered as palliative treatment.Case reports: 55 years old man diagnosed with tumor of the pancreatic head. On laparotomy performed in June 2012 tumor was stated unresectable. Histopathological examination revealed the mixed adeno-neuroendocrine cancer (MANEC). Patient was qualified to chemotherapy with gemcitabin...

Introduction: Recent data showed that PCOS is related to abnormal calcium and phosphate metabolism. The patients are characterized by elevated levels of PTH and decreased levels of vitamin D. Abnormalities in mineral homeostasis are related to insulin resistance. In this study, we assessed a complex of calcium and phosphate metabolism indices in patients diagnosed with PCOS.Material and methods: 60 women, aged 25±5 years diagnosed with PCOS accordin...

Introduction: Neurofibromatosis type 1 (NF1; von Recklinghausen’s disease) is an autosomal disorder with the prevalence 1 in 3,000 births. It is caused by mutation of the tumour-suppressor gene encoding neurofibromin. NF1 may affect various organs and patients are at increased risk of developing many neoplasms.Material and methods: We analysed seven cases of patients with NF1 (four females and three males) aged 19–52 who were treated at Endocri...

Histiocytosis is a disease caused by growth of histiocytes within one or more organs. Symptomatology may be very different: from isolated skin or bone lesions, by diabetes insipidus after life-threatening multisystem form. Diabetes insipidus as a symptom of pituitary can be observed many years before visibility of the changes in magnetic resonance imaging.A case of 59-year-old woman who has experienced diabetes insipidus with no other symptoms of hypopit...

Background: In Clinical Trials, Glucagon-like peptide-1 (GLP-1) receptor analogs liraglutide and semaglutide have been shown to cause weight loss, reduced systolic blood pressure, effectiveglycemic control with low rates of hypoglycemia, in patients with type 2 diabetes. Through a retrospective clinical study, the authors aimed to assess the clinical effectiveness of GLP-1 receptor agonists in the management of obesity in patients with Type 2 Diabetes.Me...

Background: Iodine deficiency is the most common cause of acquired hypothyroidism worldwide. Incidence of iodine deficiency may be rising due to usage of vegan diet.Case presentation: We present siblings aged 2.5 years boy and 6 years old girl from family who are strict vegans. Both children have been on vegan diet since birth. Boy attended hospital urgently due to significant concerns about hypothyroidism. His TSH level 2 months before admission was 187...

Glycogen storage disease type 1b is a metabolic disorder resulting in an inability to shuttle glucose-6-phosphate across the sarcoplasmic/endoplasmic reticulum (SR/ER) lumen. Mutation of the SoLute Carrier 37a4 (slc37a4) or glucose-6-phosphate transporter (G6PT) gene responsible for the distribution of G-6-P across this membrane leads to, hypoglycemia, hepatic glycogen accumulation, hyperlipidemia, resulting in life-limiting outcomes including growth retardation and neutropeni...

Hexose-6-phosphate dehydrogenase is an important factor in setting the redox status of the endo-/sarcoplasmic reticulum (ER/SR) lumen by generating the NADPH:NADP+ ratio for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) mediated glucocorticoid (GC) activation. H6PDH knockout mice (H6KO) clearly demonstrate the obligate nature of 11β-HSD1 for H6PDH, and display a vacuolating of type IIb fiber myopathy, elevated glycogen storage and type II to type...

We present two patients who have increased uptake in the thyroid on PET imaging.Mrs AN is a 76-year-old woman with hypertension, atrial fibrillation, deep vein thrombosis and primary autoimmune hypothyroidism with positive TPO antibodies on thyroxine. When abroad she had a carotid USS which discovered a thyroid nodule. Referred to us she was euthyroid with an USS finding of a 5 mm calcified nodule with no vascularity in the right thyroid. She had a FNA i...